NCT04635293

Preoperative Infusion of Levosimendan in Patients Undergoing Cardiac Surgery

Preoperative Infusion of Levosimendan in High Risk Cardiac Surgery Patients: A Retrospective Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Aretaieion University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The aim of this retrospective study will be to investigate the effect of the preoperative administration of levosimendan on the outcome of patients with compromised cardiac function undergoing cardiac surgery

Detailed description

Patients with severely reduced left ventricular ejection fraction (LVEF) face a high risk of morbidity and mortality after cardiac surgery. Impaired cardiac function preoperatively predisposes patients to low cardiac output syndrome. Levosimendan acts by a different mechanism than traditional inotropes and its preoperative use could improve the outcome of patients with cardiac failure. Specifically, it promotes vasodilation of coronary, pulmonary and systemic vessels, has an anti-inflammatory and anti-oxidant effect and enhances cardiac contractility by improving the response of the myofilaments to intracellular calcium. The aim of this retrospective study will be to investigate the effect of the preoperative administration of levosimendan on the outcome of patients with compromised cardiac function undergoing cardiac surgery.

Conditions

• Cardiac Disease
• Cardiac Failure
• Cardiac Surgery
• Inotropes
• Ejection Fraction

Interventions

Type	Name	Description
PROCEDURE	preoperative infusion of levosimendan	the study group will consist of patients who have received a continuous infusion of levosimendan 0.1 μg/kg/min for 24 hours before cardiac surgery
PROCEDURE	no preoperative infusion of levosimendan	the control group will consist of patients who proceeded to the cardiac operation without any infusion for 24 hours preoperatively

Timeline

• Start date: 2012-01-01
• Primary completion: 2020-11-09
• Completion: 2020-11-09
• First posted: 2020-11-19
• Last updated: 2020-11-19

Locations

1 site across 1 country: Greece