NCT04629625

End-range Mobilization on Time Curve of Pressure Pain Threshold

The Effect of End-range Mobilization on Time Curve of Pressure Pain Threshold in Knee Osteoarthritis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 66 (actual)
• Sponsor: University of Pecs · Academic / Other
• Sex: All
• Age: 60 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Pain in knee osteoarthritis (OA) represents increased pain intensity due to peripheral and central sensitivity. Pressure pain threshold (PPT) is a widely applied technique for measuring the magnitude of peripheral and central sensitivity in knee OA. Despite several manual therapy techniques has been proven to increase PPT in knee OA, the effect of end-range mobilization on the time curve of PPT has not been evaluated so far in knee OA. The aim of this study was to investigate the effect of end-range mobilization on the time curve of PPT and some function-related measures in knee OA.

Detailed description

Knee osteoarthritis (OA) is the most common form of arthritis leading to a major disability worldwide. Although many mechanisms may contribute to knee pain severity, the patient-reported hyperalgesia can be attributed to peripheral and central sensitivity in knee OA. Amongst quantitative sensory testing methods, pressure pain threshold (PPT) measurement is a simple and commonly applied method for measuring somatosensory function in musculoskeletal disorders, just as in knee OA. Many trials have presented lower PPT in knee OA compared to healthy controls underlining the presence of peripheral and central sensitivity. The different joint-based mobilization techniques may not only alleviate pain, but also increase pain tolerance to the locally applied mechanical pressure. Positive results of these techniques on increase of PPT has been reported in knee OA; however, the time curve of PPT has not evaluated so far in knee OA. Therefore, the aim of this study was to investigate the effect of end-range mobilization on the time curve of PPT and some function-related measures in knee OA.

Conditions

• Knee Osteoarthritis

Interventions

Type	Name	Description
BIOLOGICAL	End-range mobilization	End-range mobilization performed in end-range of the tibiofemoral joints' flexion and extension
BIOLOGICAL	Non end-range mobilization	Non end-range mobilization performed in tibiofemoral joints' loose position
BIOLOGICAL	Placebo	Hands-on technique performed in end-range of the tibiofemoral joints' flexion and extension

Timeline

• Start date: 2020-10-10
• Primary completion: 2021-01-02
• Completion: 2021-05-01
• First posted: 2020-11-16
• Last updated: 2022-09-08

Locations

2 sites across 1 country: Hungary