NCT04627545

Co-incubation of Oocytes With Sperm: Defining the Optimal Incubation Time

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 55 (actual)
• Sponsor: ART Fertility Clinics LLC · Academic / Other
• Sex: Female
• Age: 18 Years – 43 Years
• Healthy volunteers: Accepted

Summary

The current pilot study aims to evaluate the fertilization rates between sibling oocytes subjected to short incubation (2h) versus overnight incubation (16-20h). As secondary objectives, the abnormal fertilization, embryo development, blastocyst biopsy and euploid rates will be analyzed.

Detailed description

All patients for whom at least 6 cumulus oocytes complexes (COCs) are assigned to IVF, with normal sperm parameters, are eligible for the study. An electronically generated randomization list will allocate the first half of the oocytes to one arm and the other half of the oocytes to the second arm. In case an odd number of oocytes will be inseminated, one extra oocyte will be allocated to the first arm. In this prospective observational pilot study, the fertilization potential of 40 patients will be evaluated.

Conditions

• Infertility

Interventions

Type	Name	Description
OTHER	2h exposure to sperm for IVF	Oocytes will only be briefly (2h) exposed to progressive motile sperm for insemination
OTHER	overnight exposure to sperm for IVF	Oocytes will be exposed for a longer duration (overnight, 16-20h) to progressive motile sperm for insemination

Timeline

• Start date: 2020-11-03
• Primary completion: 2023-06-01
• Completion: 2023-07-30
• First posted: 2020-11-13
• Last updated: 2024-08-12

Locations

1 site across 1 country: United Arab Emirates