NCT04626401

Forearm Immobilization, Metabolic Health, and Nutrition

The Impact of Dietary Branched-chain Amino Acid (BCAA) Restriction on the Development of Insulin Resistance and Anabolic Resistance During Forearm Immobilization in Healthy, Young Volunteers.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: University of Exeter · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The present study will investigate the impact of dietary branched chain amino acid restriction on muscle atrophy, insulin sensitivity and muscle protein synthesis following short-term forearm immobilization

Detailed description

Twenty-four healthy young volunteers will undergo 2 days of forearm immobilization in combination with either a branched chain amino acid restricted diet or a control diet. Before and after immobilization, they will receive a stable isotope tracer infusion (5.5 h) combined with repeated blood and muscle sampling under insulin clamp conditions, in order to measure insulin sensitivity and muscle protein synthesis in the fasted and fed state.

Conditions

• Healthy

Interventions

Type	Name	Description
BEHAVIORAL	Forearm immobilization	Two days of forearm immobilization

Timeline

• Start date: 2021-06-24
• Primary completion: 2022-06-10
• Completion: 2022-06-10
• First posted: 2020-11-12
• Last updated: 2022-08-25

Locations

1 site across 1 country: United Kingdom