Trials / Active Not Recruiting
Active Not RecruitingNCT04625751
Neurovascular Coupling and Autonomic Neuropathy in Type 2 Diabetes
Unravelling the Association Between Neurovascular Uncoupling and Autonomic Neuropathy in Patients With Type 2 Diabetes
- Status
- Active Not Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 90 (estimated)
- Sponsor
- Hartwig R. Siebner · Academic / Other
- Sex
- All
- Age
- 50 Years – 70 Years
- Healthy volunteers
- Accepted
Summary
Diabetes is a growing global health care challenge. Diabetes patients may also suffer from cardiovascular autonomic neuropathy (CAN) which may affect cerebral perfusion. The main purpose of this project is to investigate the association between CAN and disturbances in the neurovascular coupling in type 2 diabetes patients. Moreover, the purpose is also to investigate coherence between CAN and the enteric nervous system. Finally, this project aims at delineating microstructural changes in the brain tissues as a consequence of CAN.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | CO2-enriched air | To assess cardiovascular reactivity |
| OTHER | Meal response test | Meal response test to assess changes in splanchnic blood flow. |
Timeline
- Start date
- 2021-04-07
- Primary completion
- 2024-12-31
- Completion
- 2025-07-31
- First posted
- 2020-11-12
- Last updated
- 2024-04-12
Locations
2 sites across 1 country: Denmark
Source: ClinicalTrials.gov record NCT04625751. Inclusion in this directory is not an endorsement.