NCT04622917

Methylprednisolone Injections Treating Birch Pollen Induced Allergic Rhinitis.

Is the Effect of Systemic Steroids Treating Pollen Induced Allergic Rhinitis Mainly Due to a Placebo Effect

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 44 (actual)
• Sponsor: Karolinska Institutet · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

This study evaluates the effect of intramuscular injected methylprednisolone treating birch pollen induced rhinitis compared to placebo.

Detailed description

The study was an interventional single center double-blinded human randomized trial with two groups treated parallel.The first group received an intramuscular injection of Methylprednisolone 40 mg/ml 2ml x 1 as a single dose. The second group received an intramuscular injection of NaCl 0,9 mg/ml 2ml x 1 as a single dose. Symptom score and the use of medication was registered daily during the pollen peak of the season, using an electronic diary. The study was conducted during the spring of 2019.

Conditions

• Rhinitis, Allergic, Seasonal
• Hay Fever
• Pollen Allergy
• Allergic Rhinitis

Interventions

Type	Name	Description
DRUG	MethylPREDNISolone 40 Mg/mL Injectable Suspension	intramuscular injection
DRUG	NaCl 9 MG/ML Injectable Solution	Intramuscular injection

Timeline

• Start date: 2019-04-10
• Primary completion: 2022-06-20
• Completion: 2023-05-31
• First posted: 2020-11-10
• Last updated: 2024-03-15

Locations

1 site across 1 country: Sweden