Trials / Recruiting
RecruitingNCT04621201
Genomic Profiles Analysis in Children, Adolescents and Young Adult With Sarcomas
Genomic Profiles Analysis in Children, Adolescents and Young Adult With Sarcomas (SAR-GEN_ITA): a Multicenter Prospective Study
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 120 (estimated)
- Sponsor
- Azienda Ospedaliera Ospedale Infantile Regina Margherita Sant'Anna · Academic / Other
- Sex
- All
- Age
- 24 Years
- Healthy volunteers
- Not accepted
Summary
Bone and soft tissue sarcomas represent about 7-12% of all pediatric cancer and are a heterogeneous group of tumors arising in connective tissues embryologically derived from the mesenchyme. For some of these tumors relapse and mortality rates are still significantly high. Therefore, further studies are needed to better understand pathogenetic processes underlying sarcomas to offer new and more effective treatments. Next generation sequencing (NGS) has opened new frontiers for cancer research allowing to identify somatic or constitutional mutations known or yet unknown with the aim to better understand carcinogenesis. The establishment of the genomic profile of the tumor could also help clinicians to personalize patients treatment based on their genetic and molecular alterations.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | observation and biopsy | biopsy |
Timeline
- Start date
- 2018-12-06
- Primary completion
- 2024-12-06
- Completion
- 2026-12-06
- First posted
- 2020-11-09
- Last updated
- 2023-03-29
Locations
10 sites across 1 country: Italy
Source: ClinicalTrials.gov record NCT04621201. Inclusion in this directory is not an endorsement.