NCT04620278

Genetic Investigation of Cancer Predisposition

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: The University of Texas Health Science Center at San Antonio · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Clinical information and samples (blood, saliva, and tumor) will be collected from patients with multiple cancers and/or a family history of cancer as well as from affected and unaffected relatives; samples will be systematically sequenced and evaluated for candidate driver mutations.

Detailed description

Genetic screening will be performed on DNA (and/or RNA) isolated from collected samples from affected individuals by whole exome sequencing or RNA sequencing using in-house pipeline to identify candidate sequence variants. These variants will be tested for segregation with the phenotype in other relatives (affected/unaffected). Candidate variants will be subjected to additional downstream analysis, to be guided by the actual type of gene/variant.

Conditions

• Genetic Predisposition
• Cancer

Interventions

Type	Name	Description
GENETIC	DNA or RNA Sequencing	Samples will be used for whole exome (DNA) or RNA sequencing

Timeline

• Start date: 2026-10-01
• Primary completion: 2030-06-01
• Completion: 2035-12-01
• First posted: 2020-11-06
• Last updated: 2026-01-06

Locations

1 site across 1 country: United States