NCT04619524

Biomarkers of Endometrial Receptivity

Biomarkers of Endometrial Receptivity: A Prospective Multicenter Study on Proteomic Biomarkers of Endometrial Receptivity in Cervical Mucus ( PRO BIOMER - CM )

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 476 (estimated)
• Sponsor: The Institute of Molecular and Translational Medicine, Czech Republic · Academic / Other
• Sex: Female
• Age: 36 Years
• Healthy volunteers: Not accepted

Summary

Analysis of proteins from cervical mucus will be done in patients undergoing infertility treatment (fresh or frozen embryo transfer). Cervical mucus will be analysed for potential new biomarkers of endometrium receptivity. Comparison of the peptide spectrum will be done for the pregnant and not pregnant patients.

Detailed description

Successful implantation depends on synchronization between a normal functional embryo at the blastocyst developmental stage and a receptive endometrium. The endometrium is receptive to blastocysts during a spatially and temporally restricted time window called the "window of implantation". Failure of the endometrium to attain receptivity is one cause of infertility, and this is not currently assessed during infertility workup due to a lack of reliable markers for receptivity. Better tests are required to assist the clinician with the decision when to defer a transfer and to freeze all embryos. Proteomics, or the analysis of the proteins in any sample, provides physiologically relevant information, since there are many regulatory steps between the transcriptome and functional proteins. Uterine fluid is a protein-rich histotroph that contains, among other components, secretions from the endometrial glands and cleavage products of both the secreted proteins and the glycocalyx. The aim of this study is to assess the highly sensitive mass spectrometer analysis of the proteins from cervical mucus for the detection of defects in endometrial receptivity and search for new endometrial receptivity biomarkers.

Conditions

• IVF
• Infertility Treatment
• Fertility Disorders
• Embryo Transfer

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Cervical mucus will be collected from patients undergoing IVF	Patients undergoing hormonal stimulation for IVF will be sampled for cervical mucus.
DIAGNOSTIC_TEST	Cervical mucus will be collected from patients undergoing transfer of cryopreserved embryos	Patients undergoing hormonal substitution for transfer of cryopreserved embryos will be sampled for cervical mucus.

Timeline

• Start date: 2018-05-01
• Primary completion: 2026-12-31
• Completion: 2026-12-31
• First posted: 2020-11-06
• Last updated: 2026-03-20

Locations

3 sites across 1 country: Czechia