NCT04619017

Airway Immune Response to Allergens (Use Lay Language Here)

Airway Dendritic Cells in the Allergic Asthma Phenotype

• Status: Unknown
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: JOSALYN CHO · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Most asthma is allergic in origin. The purpose of this study is to better understand the airway immune response to inhaled allergens in order to identify factors that promote asthma.

Detailed description

Allergy is the strongest risk factor for asthma, and most cases of asthma are allergic in origin. However, not all allergic patients have asthma. In this study, we will enroll allergic adults to undergo bronchoscopic segmental allergen challenge in order to identify differences in the airway immune response to allergen in those with asthma compared to those without asthma. After a discussion about the study and potential risks, subjects giving written informed consent will undergo two bronchoscopies. During the first procedure, samples will be collected from the left lung and allergen will be administered to a small segment of the right lung. The second procedure will be performed 24 hours later, with collection of samples from the allergen-challenged lung segment.

Conditions

• Allergic Asthma
• Allergy to Cats
• Allergy to Dust Mites
• Allergic Rhinitis
• Allergic Conjunctivitis

Interventions

Type	Name	Description
BIOLOGICAL	Segmental allergen challenge	All subjects will undergo bronchoscopy with administration of standardized allergen extract to one segment of the lung.

Timeline

• Start date: 2021-10-28
• Primary completion: 2023-04-08
• Completion: 2024-03-01
• First posted: 2020-11-06
• Last updated: 2023-08-31

Locations

2 sites across 1 country: United States

Regulatory

• FDA-regulated drug study