NCT04617717

Personalized Treatment for Patients With Premature Ventricular Beats

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 224 (estimated)
• Sponsor: Oslo University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Frequent premature ventricular beats (PVBs) are common, negatively affects the quality of life for many patients, and can lead to impaired contractile function. Rule-out of structural heart disease is key in the assessment of PVBs. Cardiac MR has a high sensitivity for structural heart disease, but the diagnostic gain from this resource-demanding procedure in the work-up of patients with PVBs is unknown. There is a need to establish the role of MR in the evaluation of patients with PVBs to improve diagnostic efficacy, establish treatment strategies, and promote further research. This project will answer three key questions: 1) What is the diagnostic gain from cardiac MR in patients with PVBs? 2) Is MR the real gold standard to rule-out structural heart disease in patients with PVBs? 3) Can non-invasive heart rate parameters guide the strategy for induction of PVBs during invasive electrophysiological procedures?

Conditions

• Ventricular Premature Complexes

Interventions

Type	Name	Description
PROCEDURE	Invasive cardiac electrophysiological study and ablation therapy	Invasive cardiac electrophysiological study with cathecholamine provocation and pacing procedures, as well as standard 3D mapping and PVC ablation
DIAGNOSTIC_TEST	Cardiopulmonary exercise testing	Standard ergometer bicycle test
DIAGNOSTIC_TEST	Cardiac MRI	Cardiac MRI with cine-imaging and late-gadolinium enhancement
DIAGNOSTIC_TEST	Holter monitoring	24h 5 lead or 12 lead ECG recording
DIAGNOSTIC_TEST	Transthoracic echocardiography	2D echocardiography
DIAGNOSTIC_TEST	Coronary angiography	Conventional invasive coronary angiography or CT angiography as indicated

Timeline

• Start date: 2020-09-30
• Primary completion: 2024-06-30
• Completion: 2040-07-31
• First posted: 2020-11-05
• Last updated: 2023-11-02

Locations

1 site across 1 country: Norway