Trials / Unknown
UnknownNCT04617366
Dynamic Individualized rTMS Based on fNIRS
Effect of Dynamic Individualized rTMS Based on fNIRS on Upper Limb Function of Stroke Patients
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University · Academic / Other
- Sex
- All
- Age
- 40 Years – 79 Years
- Healthy volunteers
- Not accepted
Summary
Stroke patients do not respond well to the traditional repetitive transcranial magnetic stimulation (rTMS) strategy based on the competitive model. The studies found that the contralesional motion cortex has a compensatory effect on the realization of the motor function of the affected side-the compensatory model, and the degree of compensation will change as the function changes. The optimal neural regulation strategies under different models are opposite, so it is important to accurately evaluate which of the two models plays the leading role. And functional near-infrared spectroscopy (fNIRS) may accurately and quickly assess cortical function in order to determine the degree of participation of the contralesional motion cortex. We propose that the dynamic individualized strategy which adjust the rTMS parameters promptly based on the results of fNIRS will be better than the traditional stimulation strategy. This project will apply a blinded-assessment randomized controlled trial. The test group selects either the high-frequency rTMS to the contralesional dorsal premotor cortex (PMd) or the low-frequency rTMS to the contralesional primary motor cortex (M1) based on the lateralization index of the PMd measured by fNIRS. And the control group will always be given low-frequency rTMS to contralesional M1. The difference in the improvement of upper limb function between the two groups of patients was compared.
Conditions
- Stroke
- Rehabilitation
- Repetitive Transcranial Magnetic Stimulation
- Functional Near-infrared Spectroscopy
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Individualized rTMS strategy | It will adjust the rTMS parameters based on the results of fNIRS. |
| OTHER | Traditional rTMS strategy | The patients will always be given low-frequency rTMS to contralesional M1. |
Timeline
- Start date
- 2020-11-05
- Primary completion
- 2023-12-31
- Completion
- 2024-03-31
- First posted
- 2020-11-05
- Last updated
- 2022-02-23
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT04617366. Inclusion in this directory is not an endorsement.