NCT04615221

Immunological Mechanisms of Rejection in Uterine Transplantation

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Hopital Foch · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

The objective of this study is to understand the mechanisms of rejection in uterine transplantation and to search for non-invasive markers of rejection. The biological samples necessary for our research have been or will be collected during procedures (biopsies, smears, vaginal swab, blood tests) carried out as part of the scheduled follow-up of patients. These will be samples whose collection is minimally or not invasive

Detailed description

In the context of uterine transplantation, non-invasive rejection markers will be sought by different approaches, including transcriptomics on a prospective cohort of patients with different types of samples: blood, smear and biopsy. A microbiota study will also be carried out. 3 groups will be studied: 1 group of 10 patients benefiting or having benefited from a uterine transplant, 1 second group made up of their 10 donors, 1 group of 10 control women

Conditions

• Transplant Rejection

Interventions

Type	Name	Description
OTHER	Specimens	Specimens (blood, biopsy, cervical smear, vaginal swab)

Timeline

• Start date: 2020-09-21
• Primary completion: 2027-09-01
• Completion: 2033-09-01
• First posted: 2020-11-04
• Last updated: 2025-09-12

Locations

1 site across 1 country: France