NCT04613024

Beneficial Side Effects of Topiramate in Obese Patients Undergoing Total Joint Arthroplasty

Beneficial Side Effects of Topiramate in Obese Patients Undergoing Total Joint Arthroplasty, a Study of Opiate Consumption and Weight Reduction

• Status: Withdrawn
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Stanford University · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate the effects of topiramate (TPM) in obese patients with respect to weight loss and pain after total joint replacement surgery

Detailed description

Investigator hypothesize that low dose peri-operative topiramate is superior to gabapentin in reducing postoperative pain and opioid consumption after primary TJA with a more favorable side effect profile that will facilitate patient optimization via pre- and postoperative weight loss.

Conditions

• Weight Loss
• Pain, Postoperative

Interventions

Type	Name	Description
DRUG	Topamax	Experiment randomized group will be prescribed Topamax before and after surgery with follow up at regular interval
DRUG	Gabapentin	Control group will be prescribed gabapentin after surgery with follow up at regular interval

Timeline

• Start date: 2025-07-01
• Primary completion: 2025-12-01
• Completion: 2027-07-01
• First posted: 2020-11-03
• Last updated: 2025-04-11

Locations

1 site across 1 country: United States Minor Outlying Islands