NCT04609150

Vertebral Fat Quantitative MRI as a Marker of Bone Fragility in Multiple Myeloma (MYELOMEFRAGIQUANTI)

Assessment of Vertebral Fat Quantitative MRI as a Marker of Bone Fragility in Patients With Multiple Myeloma

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Multiple myeloma is a disease that causes increased bone fragility which is often revealed or complicated by vertebral fractures. Invasion of bone marrow by tumor plasma cells leads to bone destruction and reduced fat fraction. The main objective is to assess the correlation between vertebral bone marrow fat fraction and bone fragility represented by a severity score of vertebral fractures. The secondary objective is to assess the correlation with clinical and biological prognostic factors and scores..

Detailed description

Patients treated with vertebroplasty will be included during the period of the study, retrospectively or prospectively. Mains collected data are represented by : * Bone marrow fat fraction determined by MRI * Severity score for vertebral fractures * Clinical prognostic factors * Biological prognostic factors * Clinico-biological scores Descriptive statistics and correlation analyses will be performed between the measured parameters.

Conditions

• Multiple Myeloma
• Vertebral Fracture

Interventions

Type	Name	Description
OTHER	Bone marrow fat quantification by MRI	Bone marrow fat quantification by MRI at the moment of the diagnosis of vertebral fracture before treatment by vertebroplasty

Timeline

• Start date: 2020-11-01
• Primary completion: 2021-12-31
• Completion: 2022-06-01
• First posted: 2020-10-30
• Last updated: 2020-11-06

Locations

1 site across 1 country: France