NCT04609033

Implications of Different Analgesic Models on Inflammatory Markers After Laparoscopic Cholecystectomy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 110 (actual)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

Postoperative abdominal and shoulder pain that are experienced in patients undergoing laparoscopic cholecystectomy (LC) is significant. Although it is generally less sever than post open cholecystectomy pain, it still causes an avoidable distress in the first 24 hours postoperatively

Detailed description

The incidence of pain after laparoscopy may be as high as 36 to 63 percent and is attributed to the carbon dioxide gas (CO2) used to induce pneumo-peritoneum1. The residual part of CO2 remains in the peritoneal cavity for several days after the operation and causes stretching of the phrenic nerve endings, local hypothermia, and diaphragmatic irritation by carbonic acid formation

Conditions

• Perioperative Pain

Interventions

Type	Name	Description
DRUG	Bupivacaine	instillation of local anaesthetic in the abdominal cavity at the end of the procedure
DRUG	isotonic saline	instillation of local anaesthetic in the abdominal cavity at the end of the procedure
DRUG	Bupivacaine + morphine	instillation of local anaesthetic + morphine sulfate in the abdominal cavity at the end of the procedure
DRUG	Bupivacaine + morphine + ketamine	instillation of local anaesthetic + morphine sulfate + ketamine in the abdominal cavity at the end of the procedure

Timeline

• Start date: 2020-10-24
• Primary completion: 2021-03-01
• Completion: 2021-03-30
• First posted: 2020-10-30
• Last updated: 2021-08-30

Locations

1 site across 1 country: Egypt