NCT04606225

Losartan Effects on Emotion-memory Interaction

The Role of the Renin-angiotensin System in Emotion-memory Interactions

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: University of Electronic Science and Technology of China · Academic / Other
• Sex: Male
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to investigate whether a single dose of losartan (50 mg) can affect emotion-memory interaction in healthy humans and its underlying neural mechanisms.

Detailed description

Animal models and initial findings in humans suggest a role of the renin-angiotensin system in cognitive and emotional processes. Accumulating evidence demonstrates modulatory effects of the angiotensin antagonist losartan in the domains of memory and emotional processing. Against this background the present study aims to investigate the behavioral and neural effects of a single dose of losartan on emotional processing and emotion-memory integration in healthy subjects. In a double-blind, between-subject, placebo-controlled pharmaco-fMRI experiment, 60 male participants will be randomized to a single dose of losartan (50 mg) or placebo, and encode emotional pictures during fMRI (scheduled 90 minutes after drug administration). Then 24 hours post fMRI participants will finish a surprise recognition memory test to estimate the emotion effects on subsequent memory.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	Losartan	administration of losartan (50 mg) (oral) Cozaar Oral Tablet
DRUG	Placebo Oral Tablet	administration of placebo (oral)

Timeline

• Start date: 2020-10-10
• Primary completion: 2021-12-31
• Completion: 2022-03-31
• First posted: 2020-10-28
• Last updated: 2020-10-28

Locations

1 site across 1 country: China