NCT04604938

The Effects of Losartan on Reward Reinforcement Learning

The Role of the Renin-angiotensin System in Reward Reinforcement Learning

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: University of Electronic Science and Technology of China · Academic / Other
• Sex: Male
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

This study aims to investigate whether a single dose of losartan (50 mg) can affect learning from positive and negative outcomes and its related neural mechanisms.

Detailed description

Emerging evidence suggests that the renin-angiotensin system can impact dopamine (DA) transmission and its modulatory role in reward processing. For instance, recent animal models have found that the angiotensin antagonist losartan reduces rewarding effects of methamphetamine and nicotine by modulating DA release in the striatum.The present study thus will investigate losartan effects on reward reinforcement learning and the underlying neural mechanisms. In a double-blind, between-subject, placebo-controlled design, 60 healthy male subjects will be randomly assigned to receive single-dose losartan (50 mg) or placebo, 90 minutes before performing a probabilistic reinforcement learning task during fMRI.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	Losartan	administration of losartan (50 mg) (oral)
DRUG	Placebo oral tablet	administration of placebo (oral)

Timeline

• Start date: 2020-10-10
• Primary completion: 2021-12-31
• Completion: 2022-03-31
• First posted: 2020-10-27
• Last updated: 2020-10-27

Locations

1 site across 1 country: China