NCT04604522

Evaluating Clonogenic Epithelial Cell Populations in Patients With Bronchiolitis Obliterans Syndrome

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 15 (estimated)
• Sponsor: M.D. Anderson Cancer Center · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

This study investigates a type of cell, called abnormal clonogenic epithelial cells, in patients with bronchiolitis obliterans syndrome who have had an donor stem cell transplant or a lung transplant. Learning more about clonogenic cells in these patients may help doctors to detect signs of bronchiolitis obliterans syndrome earlier in future patients.

Detailed description

PRIMARY OBJECTIVE: I. To characterize epithelial cell phenotypes in allogeneic hematopoietic cell transplant (allo-HCT) recipients at MD Anderson Cancer Center (MDACC) and in lung transplant recipients at Houston Methodist who have bronchiolitis obliterans syndrome (BOS). OUTLINE: Patients undergo collection of blood samples and 3 brushings of the airway during standard of care (SOC) bronchoscopy. After the bronchoscopy, patients undergo 2 nasal brushings (swabs). Patients' medical records are also reviewed for data collection. After completion of study, patients are followed for up to 1 year.

Conditions

• Bronchiolitis Obliterans

Interventions

Type	Name	Description
PROCEDURE	Biospecimen Collection	Undergo collection of blood, airway brushings.
OTHER	Medical Chart Review	Patients' medical records are reviewed

Timeline

• Start date: 2020-08-27
• Primary completion: 2026-03-31
• Completion: 2026-03-31
• First posted: 2020-10-27
• Last updated: 2026-03-11

Locations

1 site across 1 country: United States