NCT04604353

Early Detection of Coronary Artery Disease by Polygenic and Metabolic Risk Scoring

Early Detection of Coronary Artery Disease by Polygenic and Metabolic Risk Scoring in at Risk Patients: Comparison With Coronary Computed Tomography

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,059 (actual)
• Sponsor: Baker Heart and Diabetes Institute · Academic / Other
• Sex: All
• Age: 40 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The overall goal of this study is to develop a combined polygenic risk score (PRS) and metabolic risk score (MRS) and determine its impact on selecting community members for CCS. The trial component of this study will compare the use of these scores to motivate people to adhere to therapy, an ongoing challenge for clinicians, by providing feedback in a meaningful form to both the clinicians and the patients.

Detailed description

Patients undergoing a polygenic risk score (PRS), metabolic risk score (MRS) and coronary calcium score (CCS) will be randomized to receive PRS and CCS information and followed for the reduction of risk over 12 months. This information will provide information about how to motivate people to adhere to therapy, by providing feedback in a meaningful form to both the clinicians and the patients.

Conditions

• Coronary Artery Disease

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Polygenic Risk Score	Risk description to patient based on PRS
DIAGNOSTIC_TEST	Coronary Calcium Score	Risk description to patient based on CCS

Timeline

• Start date: 2020-12-07
• Primary completion: 2023-12-30
• Completion: 2023-12-30
• First posted: 2020-10-27
• Last updated: 2024-08-22

Locations

1 site across 1 country: Australia