NCT04603469

Hypotension in Children With Down Syndrome With Anesthesia Induction

Incidence of Hypotension in Children With Down Syndrome During Induction of Anesthesia With Sevoflurane

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 45 (actual)
• Sponsor: Baylor College of Medicine · Academic / Other
• Sex: All
• Age: 1 Week – 18 Years
• Healthy volunteers: Not accepted

Summary

Children generally undergo induction of anesthesia by inhalation of sevoflurane. Children with Down Syndrome experience bradycardia with induction of anesthesia using sevoflurane. It is unknown if this bradycardia is isolate or results in hypotension, thus requiring treatment. Isolate bradycardia without hypotension does not require treatment and should be avoided as many of these patients have underlying cardiac anomalies.

Detailed description

Children generally undergo induction of anesthesia by inhalation of sevoflurane. This is particularly relevant for children with developmental delays as to avoid placement of an IV while awake. However, children with Down Syndrome experience bradycardia with induction of anesthesia using sevoflurane. It is unknown if this bradycardia is isolate or results in hypotension, thus requiring treatment. Isolate bradycardia without hypotension does not require treatment and should be avoided as many of these patients have underlying cardiac anomalies.

Conditions

• Hypotension on Induction

Interventions

Type	Name	Description
OTHER	Non invasive blood pressure	measurement of blood pressure during induction of general anesthesia

Timeline

• Start date: 2021-05-26
• Primary completion: 2021-10-28
• Completion: 2021-10-28
• First posted: 2020-10-26
• Last updated: 2022-07-27

Locations

1 site across 1 country: United States