NCT04603456

miRNA-155 Assay Before and After Immunotherapy and Probiotics

MicroRNA-155 Assay in Childhood Allergic Rhinitis Before and After Combined Sublingual Immunotherapy and Probiotics

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 45 (actual)
• Sponsor: Zagazig University · Other Government
• Sex: All
• Age: 5 Years – 18 Years
• Healthy volunteers: Not accepted

Summary

The investigators aimed to explore miRNA-155 change in response to sublingual immunotherapy (SLIT), probiotics and combined treatment with SLIT and probiotics in AR children.

Detailed description

Allergic rhinitis (AR) is an inflammatory state characterized by a disturbance of immunoregulatory mechanisms that leads to an amplified T helper "Th-2" response. Micro-RNAs (miRNAs) are short single-stranded RNA molecules that post transcriptionally control gene expression and can mediate allergic process. The aim of this study was to explore miRNA-155 change in response to sublingual immunotherapy (SLIT), probiotics and combined treatment with SLIT and probiotics in AR children.

Conditions

• Allergic Rhinitis

Interventions

Type	Name	Description
DRUG	Lacteol fort	Lacteol fort is a drug containing lactobacilli
DRUG	Standardized Timothy Grass Pollen	SLIT includes 2 phases build up and maintenance phases. (Jubilant HollisterStier LLC 14110 Collections Drive, Chicago USA) .
DRUG	Lacteol fort and Standardized Timothy Grass Pollen	Lacteol fort is a drug containing lactobacilli and the Standardized Timothy Grass Pollen includes 2 phases build up and maintenance phases.

Timeline

• Start date: 2018-09-01
• Primary completion: 2019-03-10
• Completion: 2019-05-01
• First posted: 2020-10-26
• Last updated: 2020-10-29

Locations

1 site across 1 country: Egypt