NCT04601350

Effect of Remimazolam Use During Perioperative Period on Brain Waves and Postoperative Cognitive Function

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Yangzhou University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Benzodiazepine sedative hypnotics are commonly used intravenous anesthetics in clinical practice. Remimazolam is a new benzodiazepine with the characteristics of rapid onset, short maintenance and recovery time, no accumulation, metabolism independent of liver and kidney function, and no serious side effects, which has a good prospect for clinical application. Now we will study the effects of remimazolam on EEG and postoperative cognitive function ，in order to further understand the clinical application of remimazolam.

Conditions

• Benzodiazepine

Interventions

Type	Name	Description
DRUG	remimazolam group was induced with remimazolam 0.1 mg/kg followed by a maintenance dose of 0.1 mg·kg-1·h-1 for general anesthesia	remimazolam group was remimazolam 0.1 mg/kg followed by a maintenance dose of 0.1 mg·kg-1·h-1 for general anesthesia
DRUG	control group was induced with midazolam 0.05 mg/kg followed by normal saline maintenance of 0.1 ml·kg-1·h-1	control group was induced with midazolam 0.05 mg/kg followed by normal saline maintenance of 0.1 ml·kg-1·h-1

Timeline

• Start date: 2020-11-01
• Primary completion: 2022-05-01
• Completion: 2022-06-01
• First posted: 2020-10-23
• Last updated: 2024-01-16

Locations

1 site across 1 country: China