NCT04598581

Low Dose Radiation Therapy for Severe-Acute-Respiratory-Syndrome-Coronavirus-2 (SARS-CoV-2), COVID-19

Low Dose Radiation Therapy for Severe-Acute-Respiratory-Syndrome-Coronavirus-2 (SARS-CoV-2)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 22 (actual)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

This study is to analyse the efficacy of LD-RT for treatment of Severe-Acute-Respiratory-Syndrome-Coronavirus-2 (SARS-CoV-2).

Detailed description

Management of patients with SARS-CoV-2 presents a great challenge in the ongoing pandemic. The inflammatory reaction, evident in the later stages of the disease, is linked with high mortality rates. Pharmaceutical interventions at this stage often do not achieve the desired effects. Low Dose Radiation Therapy (LD-RT) has been utilized for treatment of inflammatory conditions because of its immunomodulatory effects. Thus, LD-RT may be an option in SARS-CoV-2 based on pre-clinical models and early clinical data. This study is to analyse the efficacy of LD-RT for treatment of Severe-Acute-Respiratory-Syndrome-Coronavirus-2 (SARS-CoV-2).

Conditions

• Severe-Acute-Respiratory-Syndrome-Coronavirus-2 (SARS-CoV-2)

Interventions

Type	Name	Description
RADIATION	Low Dose Radiation Therapy (LD-RT)	Low Dose Radiation Therapy (LD-RT) of both lungs with 1 Gray
OTHER	Sham irradiation	Sham irradiation

Timeline

• Start date: 2020-11-02
• Primary completion: 2021-04-09
• Completion: 2021-04-09
• First posted: 2020-10-22
• Last updated: 2021-04-19

Locations

1 site across 1 country: Switzerland