NCT04597502

The Effects of Terminalia Chebula Fruit Extract on the Gut Microbiome and Skin Biophysical Properties

"The Effects of Synastol TC (Standardized Terminalia Chebula Fruit Extract) on the Gut Microbiome and Skin Biophysical Properties"

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 58 (actual)
• Sponsor: Integrative Skin Science and Research · Industry
• Sex: Female
• Age: 25 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to assess the use of oral Terminalia chebula fruit extract on the gut microbiome and skin biophysical properties. The fruit is commonly used for skin treatments in India. It is thought to have antioxidant properties, reduce inflammation and affect the microorganisms in the gut. The information the investigators will learn from this study may indicate how and if oral dosing can affect the skin and gut microbiome. This may lead to an improved understanding of the skin and determine whether these oral products are effective for improving the skin's appearance.

Conditions

• Human Microbiome

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Terminalia Chebula fruit extract	Oral TC fruit extract supplement taken by mouth twice per day
DIETARY_SUPPLEMENT	Placebo	Oral placebo taken by mouth twice per day
OTHER	Topical Terminalia Chebula	Applied to both forearms and dorsal hands
OTHER	Topical Placebo	Applied to both forearms and dorsal hands

Timeline

• Start date: 2020-10-15
• Primary completion: 2022-03-29
• Completion: 2022-09-01
• First posted: 2020-10-22
• Last updated: 2022-11-15

Locations

1 site across 1 country: United States