NCT04594733

The Effect of Minocycline and N-acetylcysteine for the Treatment of Fibromyalgia

The Effect of Minocycline and N-acetylcysteine for the Treatment of Fibromyalgia: a Double-blind, Randomized, Crossover Pilot Study

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: Medical University of South Carolina · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Evaluation of the effect of combinatorial treatment of fibromyalgia patients (standard of care + minocycline + N-acetylcysteine (NAC) relative to standard of care on subjective pain measurement Revised Fibromyalgia Impact Questionnaire (FIQR).

Conditions

• Fibromyalgia

Interventions

Type	Name	Description
DRUG	minocycline (200 mg daily) and NAC (1200 mg daily) followed by placebo	minocycline (200 mg daily) and NAC (1200 mg daily) followed by placebo
DRUG	Placebo followed by minocycline (200 mg daily) and NAC (1200 mg daily)	Placebo followed by minocycline (200 mg daily) and NAC (1200 mg daily)

Timeline

• Start date: 2021-12-06
• Primary completion: 2022-08-31
• Completion: 2022-08-31
• First posted: 2020-10-20
• Last updated: 2024-01-30
• Results posted: 2024-01-30

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study