NCT04593394

Inducible Laryngeal Obstruction in Severe Asthma in Severe Asthma

Inducible Laryngeal Obstruction in Severe Asthma

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 116 (actual)
• Sponsor: Haukeland University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: —

Summary

The first part will be a comparative cross-sectional study to identify the frequency of ILO and other comorbidites among participants with asthma compared to a group of reference subjects without asthma, matched for age- and gender and race. The second part will be a longitudinally observational study study following participants for one year after the cross-sectional study. The Maat-scores ILO-symptoms and asthma-outcomes longitudinally will be evaluated, .

Detailed description

Inducible laryngeal obstruction (ILO) is characterized by inappropriate closure of the structures of the larynx causing reduced airflow. The symptoms are breathing difficulties that resemble those seen in asthmatic patients, such as dyspnea, coughing and stridor. ILO may be diagnosed by the continuous laryngoscopy during exercise test (CLE-test), where the larynx is visualized live on video as the patient runs to exhaustion on a treadmill whilst having a laryngoscope placed through the nose. The prevalence of ILO in asthmatic patients will be assesed by preforming a CLE-test twice in all participants at baseline and again after one year. Participant will be given visual feedback and instructed in breathing techniques. Others common comorbidities will be assessed by questionnaires and clinical interview. All patients with asthma will have a respiratory polygraph recording. Changes in ILO-symptoms and asthma-symptoms and outcomes will be assessed after 1 year.

Conditions

• Asthma Chronic
• Vocal Cord Dysfunction

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Continous laryngoscopy exercise test	Participants walks on a tredmill with a a flexible naso-laryngoscope in the larynx allowing visulasion of the larynx and obstructions in the larynx at the epiglottic og glottic levels are scored
DIAGNOSTIC_TEST	Overnight respiratory polygraphy	Overnight respiratory polygraphy is a continuous recording of nasal airflow, thoracic and abdominal movements, heart rate and oxygen saturation during the night used to detected sleep apnoea

Timeline

• Start date: 2020-11-01
• Primary completion: 2024-10-01
• Completion: 2024-10-01
• First posted: 2020-10-20
• Last updated: 2025-11-21

Locations

1 site across 1 country: Norway