Trials / Unknown
UnknownNCT04593108
Misoprostol With or Without Letrozole in Treatment of Missed Miscarriage
Study at Zagazig General Hospital
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 320 (estimated)
- Sponsor
- Dr.Dalia Mohammed Al Sayed Zaki · Academic / Other
- Sex
- Female
- Age
- 18 Years – 35 Years
- Healthy volunteers
- Accepted
Summary
Aim of study Compare the success rate of misoprostol with versus without letrozole as a pretreatment for medical termination of pregnancy during the first trimester. Hypothesis: Letrozole value as a pre-treatment medication for misoprostol in induction of abortion during the first trimester. Research question: Will letrozole- misoprostol protocol give better results than misoprostol- alone protocol in induction of abortion during the first trimester?
Detailed description
Aim of the Work Compare the success rate of misoprostol with versus without letrozole as a pretreatment for medical termination of pregnancy during the first trimester. Hypothesis: Letrozole value as a pre-treatment medication for misoprostol in induction of abortion during the first trimester. Research question: Will letrozole- misoprostol protocol give better results than misoprostol- alone protocol in induction of abortion during the first trimester? Primary outcome: Complete abortion (complete expulsion of products of conception with no need for curettage) within one week from the first dose of misoprostol. Secondary outcome: • Curettage (surgical evacuation of the products of conception) * Incomplete abortion (retained products of conception). * Considerable bleeding that necessitates immediate evacuation.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | Letrozole misoprostol | Letrozole give pretreatment of abortion by misoprostol |
| DRUG | Misoprostol, placebo | Give placebo pretreatment of abortion by misoprostol |
Timeline
- Start date
- 2019-01-15
- Primary completion
- 2020-10-01
- Completion
- 2020-11-15
- First posted
- 2020-10-19
- Last updated
- 2020-10-20
Locations
1 site across 1 country: Egypt
Regulatory
- FDA-regulated drug study
Source: ClinicalTrials.gov record NCT04593108. Inclusion in this directory is not an endorsement.