NCT04593082

Obesity and Pediatric Multiple Sclerosis

Obesity as a Driver of Inflammation and Brain Volume Loss in Pediatric Multiple Sclerosis.

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 116 (estimated)
• Sponsor: University of Virginia · Academic / Other
• Sex: All
• Age: 10 Years – 20 Years
• Healthy volunteers: Accepted

Summary

Obesity is one possible contributor to severity of multiple sclerosis and progression of the disease. We already know that obesity is a risk determinant for acquiring MS, yet the impact of obesity on pediatric MS disease expression and course is unknown. This study will evaluate the relationship between obesity, obesity-derived inflammatory mediators, and imaging metrics of MS severity in children. Understanding how childhood obesity contributes to MS severity/progression may yield fundamental insights into disease pathobiology - which may thereby lead to effective strategies for halting its progression in its earliest stages.

Conditions

• Multiple Sclerosis

Timeline

• Start date: 2021-06-03
• Primary completion: 2025-06-01
• Completion: 2025-06-01
• First posted: 2020-10-19
• Last updated: 2024-12-09

Locations

2 sites across 1 country: United States