NCT04588532

Characterization of BAM8-22 as a New Surrogate Model of Non-histaminergic Itch

Characterization of Bovine Adrenal Medulla (BAM8-22) as a New Surrogate Model of Non-histaminergic Itch

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Aalborg University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

With this experiment, the experimenter wish to asses if substance BAM8-22 (Bovine Adrenal Medulla) induce non-histaminergic itch.

Detailed description

With this experiment, the experimenter wish to establish if the substance BAM8-22 (Bovine Adrenal Medulla) induce a non-histaminergic itch by using the antihistamine Doxepin. The experimenter will also compare itch and the response to antihistamine of BAM8-22, histamine and cowhage.

Conditions

• Itch

Interventions

Type	Name	Description
DRUG	BAM8-22	Bovine Adrenal Medulla will be applied to 2 previously determined area on the volar forearm (one alone and one in combination with doxepin)
DRUG	Histamine	histamine will be applied to 2 previously determined area on the volar forearm (one alone and one in combination with doxepin)
DRUG	Cowhage (Mucuna Pruriens)	cowhage spicules will be applied to 2 previously determined area on the volar forearm (one alone and one in combination with doxepin)
DRUG	Doxepin	Doxepin cream (antihistamine) will be applied in 4 areas on the volar forearm

Timeline

• Start date: 2020-10-01
• Primary completion: 2021-05-01
• Completion: 2021-06-01
• First posted: 2020-10-19
• Last updated: 2021-07-21

Locations

1 site across 1 country: Denmark