NCT04586790

the Effect of Oral Vasopressors for Liberation From IV Vasopressors in Spinal Shock

The Effect of Oral Midodrine Versus Oral Desmopressin Acetate Use for Liberation From IV Noradrenaline in Intensive Care Unit Patients Recovering From Spinal Shock .

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Ahmed talaat ahmed aly · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

the study is developed to evaluate the effect of use of oral vasopressors (midodrine versus minirin) on weaning ICU patients from IV vasopressors (noradrenaline) and compare between them for efficacy in shortage the duration of IV vasopressor and has low complications and side effects.

Conditions

• Spinal Shock

Interventions

Type	Name	Description
DRUG	Midodrine Oral Tablet	midodrine group will receive midodrine 10 mg PO q 8 hr with gradual weaning of IV nor-adrenaline after receiving 4 doses of oral midodrine .
DRUG	Minirin oral tablet	Minirin group will receive minirin 60 µg PO q 8 hr with gradual weaning of IV nor-adrenaline after receiving 4 doses of oral minirin .
DRUG	Nor-Adrenaline	control group will receive IV nor-adrenaline and is gradually weaning from it according to routine hospital care without adding oral midodrine or oral minirin .

Timeline

• Start date: 2020-10-15
• Primary completion: 2021-01-01
• Completion: 2021-01-28
• First posted: 2020-10-14
• Last updated: 2020-10-14

Locations

1 site across 1 country: Egypt