NCT04583514

Testing the Adipose Expandability Hypothesis In Vivo During Overfeeding

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 58 (estimated)
• Sponsor: Pennington Biomedical Research Center · Academic / Other
• Sex: All
• Age: 18 Years – 42 Years
• Healthy volunteers: Accepted

Summary

Adipose, or fat, tissue is a plastic organ that retains the ability to expand and store excess calories during positive energy balance in humans. The capacity of subcutaneous (subQ) adipose tissue to expand and remodel is an important determinant of obesity-related health complications, and impaired expansion of subQ fat tissue is thought to contribute to the risk of diseases such as the Metabolic Syndrome (MetS) and type 2 diabetes mellitus (T2D). The objectives of the study are to evaluate the changes and mechanisms of (subQ) adipose tissue expandability that occur as a result of short-term weight gain and to investigate the effects on cardio-metabolic health outcomes. Findings from this study will provide new insight into the dynamics of adipose expansion and remodeling during changes in energy balance and how this may impact future fat tissue function and metabolic health.

Conditions

• Overweight and Obesity
• Metabolic Syndrome

Interventions

Type	Name	Description
BEHAVIORAL	Control	Weight-stable Control group
BEHAVIORAL	Overfeeding	30% Overfeeding group

Timeline

• Start date: 2020-09-15
• Primary completion: 2026-12-31
• Completion: 2026-12-31
• First posted: 2020-10-12
• Last updated: 2026-04-08

Locations

1 site across 1 country: United States