NCT04582032

Effects of Cyclooxygenase (COX) 1-2 Inhibitors on Prevention of Rocuronium Injection Pain

Effects of COX 1-2 Inhibitors on Prevention of Rocuronium Injection Pain: Controlled, Randomised, Double Blind Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 68 (actual)
• Sponsor: Ankara City Hospital Bilkent · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Purpose : The aim of the study is to investigate the effects of cox inhibitors as a rescue agent against the rocuronium pain Methodology : Sixty patients enrolled for the general anesthesia enrolled in this study. Patients were allocated into two groups (Group 1: Dexketoprofen group, Group 2: Control group) .Pain was evaluated by during rocuronium injection, patients were scored by a scale showed below. 0;No movement response to injection 1. Mild movement response to injection 2. Hand withdrawal response to injection 3. Arm withdrawal response to injection Investigators also evaluated the pain with 2 questions when the patient was in the recovery room. Question 1.What was the last feeling before participants fall into sleep? question 2. Did participants feel any pain on participants's hand during medication injection for anesthesia?

Detailed description

Purpose : Rocuronium bromide is a painful agent while general anesthesia induction. The aim of the study is to investigate the effects of cox inhibitors as a rescue agent against the rocuronium pain Methodology : Sixty patients enrolled for the general anesthesia enrolled in this study. Patients were allocated into two groups (Group 1: Dexketoprofen group, Group 2: Control group) .Pain was evaluated by during rocuronium injection, patients were scored by a scale showed below. 0;No movement response to injection 1. Mild movement response to injection 2. Hand withdrawal response to injection 3. Arm withdrawal response to injection Investigators also evaluated the pain with 2 questions when the patient was in the recovery room. Question 1.What was the last feeling before participants fall into sleep? question 2. Did participants feel any pain on participants's hand during medication injection for anesthesia?

Conditions

• Injection Site Irritation

Interventions

Type	Name	Description
DRUG	Dexketoprofen (KETAVEL 50 mg/2 ml)	intravenous dexketoprofen (KETAVEL 50 mg/2 ml)
DRUG	Saline (Isotonic Saline Solution 0.9% )	intravenous 2 ml of saline

Timeline

• Start date: 2020-11-01
• Primary completion: 2020-12-04
• Completion: 2021-01-04
• First posted: 2020-10-09
• Last updated: 2021-01-29

Locations

1 site across 1 country: Turkey (Türkiye)