Trials / Completed
CompletedNCT04580537
Assessing the Efficacy of Image-guided Laser-assisted Enstilar® Delivery for Treatment of Psoriatic Nails
Assessing the Efficacy of Image-guided Laser-assisted Enstilar® Delivery for Treatment of Psoriatic Nails - a Proof-of-concept, Single-center, Prospective, Open-label, Randomized, Clinical Trial With an Intra-individual Comparison of Treatments
- Status
- Completed
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 11 (actual)
- Sponsor
- Bispebjerg Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The trial is conducted to investigate the clinical efficacy of a combination product containing calcipotriol and betamethasone formulated as an aerosol foam (Enstilar ©) for the treatment of nail psoriasis in conjunction with physical pre-treatment using a fractionally ablative carbon dioxide laser (AFL). It is hypothesized, based on preclinical data and comparable clinical trials, that laser processing prior to topical administration will lead to increased drug distribution, and thereby increase the efficacy of Enstilar® in treating nail psoriasis.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Enstilar | Daily application on affected fingers (nail plates, nail folds, and surrounding skin) |
| DEVICE | Ablative fractional laser | Pre-treatment of affected fingers (nail plates, nail folds) |
Timeline
- Start date
- 2020-10-02
- Primary completion
- 2021-06-01
- Completion
- 2021-06-01
- First posted
- 2020-10-08
- Last updated
- 2022-03-02
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT04580537. Inclusion in this directory is not an endorsement.