NCT04580511

Safety and Clinical Performance of a Biological Matrix Used in Abdominal Wall Reconstruction

Safety and Clinical Performance of a Non-cross-linked Porcine Acellular Dermal Matrix Used in Abdominal Wall Reconstruction: an Observational Prospective Study.

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 92 (actual)
• Sponsor: Meccellis Biotech · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The general objective of the study is to confirm the medium/long-term safety and clinical performance of the CELLIS membrane used in abdominal wall reconstruction including, but not limited to, ventral hernia repair and stoma closure, and to identify emerging risks in comparison to the clinical data related to other types of fixation material. The present study will be a prospective multicentric non-randomized and noncontrolled trial involving 112 patients followed for 24 months. The study will be conducted in France in 3 investigational centres.

Detailed description

The study will be prospective, multicentric, single-arm, observational (non-interventional) to evaluate the safety and performance of the CELLIS membrane used in abdominal wall reconstruction including, but not limited to, ventral hernia repair and stoma closure. All evaluations will be performed and products used according to the usual practice, without additional or unusual diagnostic, treatment and monitoring procedure. The study will be conducted in France in 3 investigational centres including 112 patients scheduled for an abdominal wall reconstruction. Each patient will participate in one assessment period including a preoperative visit, followed by the day of surgical procedure and a hospitalization period. Patients will return for ambulatory visits on day 30 (+/- 7 days), on month 3 (+/- 2 weeks), on month 12 (+/- 2 weeks) and on month 24 (+/-2 weeks) post-surgery. CELLIS will be implanted by open technique following standard techniques. The membrane can be used in bridged or reinforced repairs. Mesh placement can include inlay (bridging), underlay intraperitoneal, sublay (retrorectus/retromuscular) positions.

Conditions

• Abdominal Wall Defect
• Abdominal Wall Injury
• Abdominal Hernia

Interventions

Type	Name	Description
DEVICE	CELLIS (Porcine Acellular Dermal Matrix, PADM)	Biological membrane used in abdominal reconstruction

Timeline

• Start date: 2020-11-04
• Primary completion: 2026-11-01
• Completion: 2026-11-01
• First posted: 2020-10-08
• Last updated: 2024-11-22

Locations

4 sites across 1 country: France