NCT04578938

Ketamine + Cognitive Training for Suicidality in the Medical Setting

• Status: Active Not Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 200 (actual)
• Sponsor: Rebecca Price · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This project seeks to identify the acute and longer-term impact of a single dose of intravenous ketamine among suicidal patients referred for psychiatric consultation/liaison in the medical inpatient setting. The investigators will then test whether ketamine's rapid effects can be extended by introducing helpful information delivered by a computer-based training protocol. This work could ultimately lead to the ability to treat suicidality more efficiently and with broader dissemination by rapidly priming the brain for helpful forms of learning.

Detailed description

NOTE: Edits were made to the outcome measures sections to improve clarity regarding the a priori analytic plan with respect to the "Time Frame" of measurements and to reduce redundancies. Timepoints that will be analyzed as trajectories over windows of time and measurements that will be analyzed as composites are now more clearly specified. The previous entries correctly identified all relevant measures and timepoints, but implied incorrectly that each timepoint/measure would be analyzed in isolation. 03/19/26: Edit to upper age limit made to correct a previous data entry error and align with IRB-approved protocol.

Conditions

• Suicide, Attempted

Interventions

Type	Name	Description
DRUG	Intravenous ketamine	Single subanesthetic infusion of ketamine (0.5mg/kg)
BEHAVIORAL	Cognitive training	8 sessions of computer-based cognitive training
BEHAVIORAL	Sham Training	8 sessions of computer-based sham training

Timeline

• Start date: 2021-03-15
• Primary completion: 2026-12-02
• Completion: 2026-12-02
• First posted: 2020-10-08
• Last updated: 2026-03-24

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study