NCT04573452

Galectin-3 and Placenta Accreta

The Role of Galectin-3 in the Pathogenesis and Prediction of Placenta Accreta

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 62 (actual)
• Sponsor: Assiut University · Academic / Other
• Sex: Female
• Age: 20 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

Galectins are a family of carbohydrate-binding proteins that have a high affinity to galactosides, its protein portion is located in the nucleus and the cytoplasm with its carbohydrate recognition domain which has high ability to be glycosylated inside or outside the cell. They are expressed by vascular endothelium, immune cells (macrophages, neutrophils, and mast cells), uterus, placenta, cardiac muscle, liver, epithelium of the gastrointestinal tract, and many other tissues. Although some galectins have intracellular functions, the majority of them have extracellular activities, which facilitate their contribution to cell adhesion, cell activation, and inflammation. Galectin-3 (Gal-3) is a unique pentamer of the galectins family and it is involved in both physiological functions; cell growth and differentiation, and pathological conditions; inflammation, fibrosis, and metastasis. Regarding pregnancy, Gal-3 is proved to participate in angiogenesis, embryo developmental processes, and modulation of maternal immunity.

Conditions

• Placenta Accreta

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Galectin-3	Measurement of Gal-3 in Serum which will be isolated from the blood samples by ELISA (Enzyme-Linked immunosorbent Assay) (R\&D Systems, Minneapolis, MN, USA).
DIAGNOSTIC_TEST	Placental Galactin-3	Measurement of Gal-3 in Villous and decidual tissues homogenate by ELISA

Timeline

• Start date: 2020-10-01
• Primary completion: 2021-10-01
• Completion: 2021-10-01
• First posted: 2020-10-05
• Last updated: 2022-10-10

Locations

1 site across 1 country: Egypt