NCT04573205

Primary TBE Vaccination for the Elderly

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Region Örebro County · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Tick-borne Encephalitis (TBE) can be prevented by vaccine. Vaccine failure, defined as a case of TBE regardless of previous vaccination, has been described and seems to be more predominant with increasing age, suggesting a less effective immune response following with increasing age. In fact previous studies has shown a reduced antibody response in elderly individuals compared to younger when vaccinated against TBE. As a result, in Sweden, an extra vaccine dose has been recommended during the primary vaccine schedule to individuals \> 50 years of age. This alternative vaccine schedule has not been tested. The investigator aim to test if an extra vaccine dose in the primary vaccine schedule for those \> 50 years of age improves the immune response and offers a corresponding immunity to younger individuals following TBE vaccination.

Conditions

• Tick-borne Encephalitis
• Vaccine

Interventions

Type	Name	Description
DRUG	FSME-IMMUN Vaccine	0.5 ml intramuscular injection scheduled in the two different arms

Timeline

• Start date: 2024-01-01
• Primary completion: 2024-01-01
• Completion: 2025-01-01
• First posted: 2020-10-05
• Last updated: 2023-11-18

Locations

1 site across 1 country: Sweden