NCT04570072

Effect of Probiotic on Comorbidity of Depression and Constipation

Effect of Probiotic on Chinese Patients With Depression and Constipated Comorbidity

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: China Agricultural University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Depressive disorder, also known as depression, is a type of mood disorder characterized by persistent low mood. The incidence of depression worldwide is about 6%. The high comorbidity rate between depression and constipation indicated the role of the gut-brain axis in depression. Growing evidence suggested that the gut microbiota plays a key role in the development of depression. Probiotics can effectively improve constipation and regulate gut microbiota, and showed potential in alleviating depression. This study investigated the effect of formula probiotic (containing Lactobacillus paracasei, Bifidobacterium animals, Bifidobacterium longum, Bifidobacterium bifidum, and Lactobacillus plantarum) on the comorbidity of depression and constipation.

Conditions

• Comorbidity of Depression and Constipation

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Probiotic	Patients receive the formula probiotic for consecutive 8 weeks ( one sachet per day ).
DIETARY_SUPPLEMENT	Placebo	Patients receive the placebo identical to probiotic for consecutive 8 weeks ( one sachet per day ).

Timeline

• Start date: 2020-11-01
• Primary completion: 2021-06-30
• Completion: 2021-12-30
• First posted: 2020-09-30
• Last updated: 2020-09-30

Locations

1 site across 1 country: China