NCT04568512

DNA Methylation Biomarker for Diagnosis of Cholangiocarcinoma in Patients With Bile Duct Stricture

DNA Methylation Biomarker in Biliary Brush Sample for Diagnosis of Cholangiocarcinoma in Patients With Bile Duct Stricture

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 67 (actual)
• Sponsor: Mahidol University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

DNA methylation biomarker for diagnosis of cholangiocarcinoma in patients with bile duct stricture has high sensitivity and specificity compared with cytology from the brush specimens

Detailed description

The methylation of HOXA1, NEUROG1 were used to determine cholangiocarcinoma from brushed biliary samples. However, the sensitivity and specificity of this test for cholangiocarcinoma is still required.

Conditions

• Cholangiocarcinoma
• Biliary Stricture
• DNA Methylation
• Brush Cytology

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Control	Brushed biliary samples from a known case of benign biliary stricture were sent for DNA Methylation Biomarker test and cell cytology
DIAGNOSTIC_TEST	Cholangiocarcinoma	Brushed biliary samples from a known case of cholangiocarcinoma were sent for DNA Methylation Biomarker test and cell cytology

Timeline

• Start date: 2016-01-01
• Primary completion: 2019-12-31
• Completion: 2019-12-31
• First posted: 2020-09-29
• Last updated: 2020-09-29

Locations

1 site across 1 country: Thailand