NCT04564183

Advancing Prevention of Pulmonary Fibrosis

Advancing Prevention of Pulmonary Fibrosis - A Cohort Study of Preclinical Pulmonary Fibrosis

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 800 (estimated)
• Sponsor: University of Colorado, Denver · Academic / Other
• Sex: All
• Age: 40 Years – 75 Years
• Healthy volunteers: Accepted

Summary

This study plans to learn more about pulmonary fibrosis and how it develops. We want to determine if the disease can be detected early, before the lung is permanently scarred. This study will enroll participants who are not currently diagnosed with pulmonary fibrosis, but who have family members with pulmonary fibrosis. Because there is an increased risk within affected families, this cohort will allow us to learn how pulmonary fibrosis develops, and how the lungs change over time.

Conditions

• IPF
• Pulmonary Fibrosis
• ILD

Interventions

Type	Name	Description
OTHER	Sample collection	Blood, Urine, Nail, Hair, Saliva, optional Stool
OTHER	Questionnaires	SF-36, Food Frequency, Pulmonary Fibrosis Study questionnaire, COVID questionnaire
RADIATION	High resolution CT scan of the chest	Upon enrollment, all participants will undergo single prone volumetric thoracic chest CT scan. This will be performed at full inspiration using a 64-slice CT scanner.
DIAGNOSTIC_TEST	Pulmonary Function Test	All recruited participants will undergo a pre-bronchodilator spirometry test and a lung diffusion capacity test, both in accordance with ATS guidelines. Exercise capacity (maximum physical exertion) will be assessed by performing a 6-minute walk test, also according to ATS guidelines.

Timeline

• Start date: 2021-01-22
• Primary completion: 2026-08-01
• Completion: 2026-08-01
• First posted: 2020-09-25
• Last updated: 2025-03-25

Locations

1 site across 1 country: United States