NCT04563650

COVID-19 Serology and Immunosenescence

Kinetics of COVID-19-neutralising Antibodies in Patients Residing in EHPAD / USLD: Influence of Immunosenescence

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 98 (actual)
• Sponsor: Centre Hospitalier Universitaire, Amiens · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to determine how long COVID-19 neutralizing antibodies can be detected in an elderly institutionalized population presenting fragility factors. This study also aims to stratify seroconversion by immunological profiles of the elderly patients residing in the EHPAD. This stratification requires the measurement of immunological marker levels already described in immunosenescence and also involved in the development of certain chronic infectious diseases more common in the elderly population. This analysis will enable the investigators to describe an immunological, clinical and biological profile representing a patient who has developed an immunity against COVID 19. It will also help the investigators to understand the different mechanisms leading to a reduced immune response after a potential administration of a vaccine. Finally, it will help describe the immune profiles of elderly residents who presented with non-severe forms of COVID-19.

Conditions

• Covid19
• Geriatric Medicine
• Seroconversion
• Immunosenescence

Interventions

Type	Name	Description
BIOLOGICAL	blood sample	Sample collection of 4 to 10 tubes of whole blood will be done according to centre Saint-Victor's protocol.

Timeline

• Start date: 2020-09-18
• Primary completion: 2021-05-01
• Completion: 2024-11-01
• First posted: 2020-09-24
• Last updated: 2024-04-10

Locations

1 site across 1 country: France