NCT04563260

Effect of Palonosetron on Remifentanil for Preventing Emergence Cough in Female

Effect of Palonosetron on Effect-site Concentration of Remifentanil for Preventing Emergence Cough During General Anesthesia in Female Patients Undergoing Laparoscopic Cholecystectomy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (actual)
• Sponsor: Ajou University School of Medicine · Academic / Other
• Sex: Female
• Age: 19 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The primary purpose of this study is to investigate the optimal Ce of remifentanil for preventing emergence cough following extubation during general anesthesia in female patients who receive the palonosetron or not.

Detailed description

Remifentanil is a potent ultrashort-acting opioid, with rapid onset and offset of drug effect. It allows rapid anesthetic emergence even after a prolonged infusion, and decreases the at-risk time during extubation. In addition, cough suppression of remifentanil enables smooth extubation with reduced complications. However, the infusion of remifentanil suppresses the emergence cough effectively in clinical practice, whereas it still delays the awakening from anesthesia, resulting in prolonged emergence time. Reduced Ce of remifentanil during emergence would decrease the adverse events that are associated with remifentanil infusion.

Conditions

• Gallbladder Diseases

Interventions

Type	Name	Description
DRUG	Normal saline injection	Normal saline 2 mL, intravenous injection
DRUG	Palonosetron Injection [Aloxi]	Palonosetron 1.5 mL (0.075 mg) + Normal saline 0.5 mL, intravenous injection

Timeline

• Start date: 2020-10-07
• Primary completion: 2021-03-19
• Completion: 2021-03-19
• First posted: 2020-09-24
• Last updated: 2021-05-11

Locations

1 site across 1 country: South Korea