NCT04558983

A Natural History Study to Evaluate Functional and Anatomical Progression in Retinitis Pigmentosa

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 32 (actual)
• Sponsor: Johns Hopkins University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study will assess the progression of RP as seen on newer modalities including spectral-domain optical coherence (SD-OCT) and macular assessment integrity (MAIA) microperimetry to evaluate disease status. Understanding the natural history of the disease is not only essential to monitoring and comparing patient populations in clinical trials. It is also fundamental in the predevelopment phase in order to optimize the study duration needed to observe a statistically significant outcome. Furthermore, since the progression of RP is usually slow, relying on traditional tests can take an unfeasible length of time to observe any meaningful changes and assess therapeutic efficacy for new drugs. Therefore, the results of this study will be beneficial in establishing reliable endpoints and outcome measures for future clinical trials. Such outcome measures may be able to detect treatment response with more precision. More importantly, investigators may be able to detect changes early enough to prevent irreversible vision loss.

Conditions

• Retinitis Pigmentosa

Timeline

• Start date: 2020-06-11
• Primary completion: 2024-12-20
• Completion: 2024-12-20
• First posted: 2020-09-22
• Last updated: 2024-12-27

Locations

1 site across 1 country: United States