NCT04558333

CLAD: Finding Biomarkers to Predict Rejection and/ or Outcome After Lung Transplantation

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 24 (actual)
• Sponsor: University Hospital, Antwerp · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Lung transplantation is the ultimate treatment for end stage lung diseases. Survival after lung transplantation is limited mainly due to the development of chronic allograft dysfunction (CLAD). Both acute cellular rejection and primary grade dysfunction (PGD) have been associated with the development of CLAD. In this study we will investigate multiple prognostic factors that influence long term survival after lung transplantation with a specific interest in PGD, acute rejection and the development of CLAD.

Detailed description

At specific time points (according to protocol) exhaled breath, blood specimens, bronchoalveolar lavage and biopsies will be collected. These will be analyzed in an attempt to identify possible biomarkers that will predict the development of PGD and/or CLAD.

Conditions

• Lung Transplant Failure and Rejection
• Primary Graft Dysfunction

Interventions

Type	Name	Description
OTHER	blood and exhaled breath specimens	identification of possible biomarkers

Timeline

• Start date: 2019-10-28
• Primary completion: 2024-02-28
• Completion: 2024-02-28
• First posted: 2020-09-22
• Last updated: 2024-05-03

Locations

1 site across 1 country: Belgium