NCT04556929

Enhanced Detection in Glioma Excision

Improving Fluorescence-guided Brain Tumour Surgery With Ultra-high Sensitivity Imaging

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 4 (actual)
• Sponsor: University of Oxford · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether use of an ultra-high sensitivity camera with enhanced imaging technology can be used during surgery to detect areas of brain tissue affected by diffuse glioma, a type of brain cancer.

Conditions

• Glioma

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Intra-operative imaging of 5-ALA fluorescence using ultra-high sensitivity camera	An ultra-high sensitivity camera attached to the side arm of the operative microscope will be used to take images of the anterior, posterior, lateral and inferior walls of the resection cavity on completion of tumour resection.
DIAGNOSTIC_TEST	Intra-operative imaging of 5-ALA fluorescence using in-built operative microscope camera	In-built camera of the operative microscope will be used to take images of the anterior, posterior, lateral and inferior walls of the resection cavity on completion of tumour resection.
DIAGNOSTIC_TEST	Biopsies	Following image capture, biopsies (approx 5x5x5mm size) will be taken from regions of the anterior, posterior, lateral and inferior walls of the resection cavity corresponding to the imaged areas.

Timeline

• Start date: 2020-09-21
• Primary completion: 2021-11-03
• Completion: 2021-11-03
• First posted: 2020-09-21
• Last updated: 2024-03-22

Locations

1 site across 1 country: United Kingdom