NCT04554888

Characterization of New Human Models of Non-histaminergic Itch and Their Interaction With the TRPM8 Receptor

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Aalborg University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

In this experiment the investigators would like to assess if papain induces an itch sensation comparable to the itch sensation induced by cowhage and to confirm that the mechanism of action of papain follows the non-histaminergic pathway.

Conditions

• Itch

Interventions

Type	Name	Description
DRUG	Doxepin Topical	Four of the areas will be treated with doxepin for 1 hour and 30 minutes (with a patch to deposit 1.2 grams of cream). Each patch will be covered with Tegaderm I.V., an occlusive, adhesive dressing (3M), for at least 1½ hours
DRUG	Papain	Papain will be applied by 1 SPT prick thought the skin
DRUG	Histamine	Histamine will be applied by 1 SPT prick thought the skin
OTHER	Cowhage	Cowhage spicules are 1-2 mm in length and have diameter of 1-3 µm at their tip. 30-35 spicules are gently rubbed into a 1 cm diameter skin area.

Timeline

• Start date: 2022-03-01
• Primary completion: 2022-05-31
• Completion: 2022-06-30
• First posted: 2020-09-18
• Last updated: 2022-07-20

Locations

1 site across 1 country: Denmark