NCT04554004

A Non-invasive Index of Microciculatory Resistance

A Clinical Trial for CT Myocardial Perfusion Based Non-invasive Index of Microciculatory Resistance

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 295 (actual)
• Sponsor: First People's Hospital of Hangzhou · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Coronary artery microvascular disease (CMVD) lacks reliable and non-invasive quantitative diagnosis methods. Improving coronary microcirculation has become one of the main goals of coronary heart disease treatment. In this study, by establishing the key influencing factors of myocardial microcirculation perfusion, an accurate three-dimensional reconstruction method of coronary artery was established, and a non-invasive coronary microcirculation resistance index (CT-IMR) calculation method based on computational fluid method mechanics was established. At the same time, a phase I single-center clinical verification and a multi-center clinical verification of the non-invasive coronary microcirculation function precision assessment system were carried out, and a non-invasive coronary microcirculation detection system and technology were established.

Conditions

• Coronary Microvascular Disease
• Coronary Artery Disease

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	CCTA, CT-MPI, DSA, FFR	The patients who enrolled the study will undergo coronary CT angiography(CCTA), dynamic CT-MPI, invasive coronary angiography and invasive computation of fractional flow reserve (FFR)

Timeline

• Start date: 2022-12-15
• Primary completion: 2024-12-31
• Completion: 2024-12-31
• First posted: 2020-09-18
• Last updated: 2025-06-04

Locations

1 site across 1 country: China