NCT04553900

Effect of Heat Stress on Global LV Function in Anesthetized Humans

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: University of California, San Diego · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Recent data suggests that increased temperature improves inotropic function during systole and may improve diastolic function in healthy humans at rest, despite a reduction in left ventricular volume at end diastole. The effect of heat stress has not been reported in patients receiving general anesthesia and the impact of general anesthesia on these findings is not known. Trans-esophageal echocardiography will be used to measure parameters important to both systolic and diastolic function at temperature intervals of 1°C in patients undergoing "Heated Intraoperative Peritoneal Chemotherapy" (HIPEC.) That general anesthesia will not alter the cardiovascular effects of increased temperature that has been reported in healthy, un-anesthetized humans is the hypothesis.

Conditions

• Hyperthermia
• Cardiac Functional Disturbances During Surgery

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Transesophageal Echocardiography	Placement of a transesophageal probe and performance of a diagnostic Transesophageal echocardiography examination.

Timeline

• Start date: 2017-06-09
• Primary completion: 2019-12-06
• Completion: 2019-12-06
• First posted: 2020-09-18
• Last updated: 2020-09-21

Locations

1 site across 1 country: United States