NCT04553705

Omega-3, Nigella Sativa, Indian Costus, Quinine, Anise Seed, Deglycyrrhizinated Licorice, Artemisinin, Febrifugine on Immunity of Patients With (COVID-19)

Impact of Different Treatment Modalities on Immunity Against COVID-19

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 150 (actual)
• Sponsor: Beni-Suef University · Academic / Other
• Sex: All
• Age: 25 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

The first version of this preprint article is registered on the 4th of May 2020 under the digital object identifier of:10.31219/osf.io/u56fc. COVID-19 infections virus spread worldwide and impact many countries with sever economical sequences. The effective antiviral medication or vaccination for the virus is unavailable until the present date and it takes months or years to discover the effective treatment or test the efficacy of the discovered treatment. Based on these facts, the human immune system against the virus may have an effective role to regulate the infection and reduce the mortality rate among the infected patients. This proposed research article aims to explore the available medication/ natural supplementation to boost the immunity system of the patients against COVID-19 infections and reduce the mortality rate among infected patients. Methods: a proposed clinical trial will be carried out to investigate the effect of the different treatment modalities on the human immune system against COVID-19 infection.

Detailed description

Natural supplementations have many reported effects on the human health ranged from immunity boosting to effective antiviral effect. Omeg-3 as an example affect the human health by many mechanisms e.g. Anti-oxidant, immunity boosting agent. Moreover, Omega-3 exerts an antiviral effect on Flu virus by inhibiting influenza virus replication 1. On the other hand, black seed supplementation exerts a chelation effect on sickle cell anemia patients and inhibits Human Heme Metabolism 2. Moreover, black seed exerts an antiviral effect on the replication of old coronavirus and the expression of (TRP-genes) family 3. In addition, Omega-3 regulates the human immunity against bacterial and viral infections 4. During the past years, many natural sources exerts an antimalarial effect with perfect reported results 5.

Conditions

• Covid19
• Immunodeficiency

Interventions

Type	Name	Description
DRUG	Omega 3/Nigella Sativa Oil	Omega-3 supplementation 1000mg contains (300-400mg EPA \& 200-300mg DHA) Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone
DRUG	Omega 3/Nigella Sativa Oil/Indian Costus	Omega-3 supplementation 1000mg contains (300-400mg EPA \& 200-300mg DHA) Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone Indian Costus supplements
DRUG	Omega 3/Nigella Sativa Oil/Quinine pills	Omega-3 supplementation 1000mg contains (300-400mg EPA \& 200-300mg DHA) Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone Quinine supplementation (1g Quinine)
DRUG	Omega 3/Nigella Sativa Oil/Anise seed capsule	Omega-3 supplementation 1000mg contains (300-400mg EPA \& 200-300mg DHA) Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone Anise seed supplementation (450mg anise seed)
DRUG	Omega 3/Nigella Sativa Oil/Deglycyrrhizinated Licorice	Omega-3 supplementation 1000mg contains (300-400mg EPA \& 200-300mg DHA) Nigella sativa supplementation (1g black seed oil contain 3% thymoquinone Deglycyrrhizinated Licorice 800 mg
DRUG	Active Comparator	Standard protocol care of COVID-19 infection

Timeline

• Start date: 2020-09-20
• Primary completion: 2020-11-04
• Completion: 2021-12-04
• First posted: 2020-09-17
• Last updated: 2025-09-23

Locations

1 site across 1 country: Saudi Arabia